Disabled homolog 2 (DAB2), as a member of the disable gene family, has been proven to function as a tumor suppressor that plays an crucial role in the occurrence and progression of various tumors (Albertsen et al., 1996), including colorectal cancer (Kleeff et al., 2002) and epithelial ovarian cancer (Mok et al., 1998). The gene discussed is DAB2; the disease is colorectal cancer.