RB1 and cervical carcinoma: It is well accepted that the functional inactivation of p53 and Rb tumor suppressor proteins by the HPV E6 and E7 oncoproteins is a crucial mechanism in the carcinogenesis of cervical cancer (Yim and Park, 2005; Jiang et al., 2019; Gutiérrez-Hoya and Soto-Cruz, 2020).