Besides YAP/TAZ, hemodynamic forces activate a number of signaling pathways to regulate endothelial phenotypes associated with atherosclerosis, via other transcription factors, such as KLF2, KLF4, NRF2, HIF-1α, NF-κB, AP-1, and a few others (Niu et al., 2019). This evidence concerns the gene YAP1 and atherosclerosis.