Mechanistically, the ECM-activated YAP/TAZ regulates the expression of various cytoskeletal regulators in cancer-associated fibroblasts and increases intracellular isometric tension, thus forming a forward feedback loop to enhance the tumor microenvironmental rigidity and support cancer cell growth and invasion (Calvo et al., 2013; Foster et al., 2017). This evidence concerns the gene YAP1 and neoplasm.