YAP1 and cancer: Numerous studies have documented that stiff substrates activate YAP/TAZ to increase primary cancer cell growth, migration, and chemotherapy resistance (Lin et al., 2015; Chakraborty et al., 2017; Foster et al., 2017; Meng et al., 2018; Santinon et al., 2018; Molina et al., 2019; Ghasemi et al., 2020; Liu et al., 2020; Qin et al., 2020).