Therefore, in this study, we established a DHT-induced hyperandrogenic mouse model (Manneras et al., 2007; van Houten et al., 2012) and hyperandrogenic cell models to explore the effects of androgen and the mechanism of Col6a5. Our findings highlight the importance of Col6a5-mediated androgen actions in lipid metabolism disorder and the process of ovarian stromal cell and adipocyte hypertrophy. This evidence concerns the gene COL6A5 and Disorder of lipid metabolism.