BRD7 and infectious otitis media: Unexpectedly, DAI was markedly reduced in the late stage of AOM/DSS-induced CRC in BRD7–/– mice, and 70% of BRD7+/+ mice developed CAC, while there were no tumors in the BRD7–/– group on day 126, indicating that BRD7 plays a pro-inflammatory role and potentially plays an oncogenic role in the late stage of AOM/DSS-induced CRC in mice.