MYC and cancer: Unfortunately, although the functional role and mechanism of c-Myc is well-defined in promoting cell proliferation in many cancers, no anti-cancer strategies that directly target c-Myc protein are available for clinical cancer treatment (Koh et al., 2016), owing to its “undruggable” protein structure (Bachmann and Geerts, 2018; Yoshida, 2018; Wang et al., 2019).