To exclude the genetic inactivation caused by chemical-induced mutations, we detected the ORF sequences of BRD7 in tumors of BRD7+/+ mice and confirmed that there were no mutants in the BRD7 ORF as shown in Supplementary Figure 1, which suggest that the mechanism that BRD7 promotes tumor development and that growth is not dependent on the loss of a tumor-suppressive role resulted from AOM/DSS-driven BRD7 mutation but exerts oncogenic roles. This evidence concerns the gene BRD7 and infectious otitis media.