BRD7 and colitis: As a result, BRD7–/– mice show an increased DAI before the 14th day than did BRD7+/+ mice, which is consistent with our previous results (Zhao et al., 2017), but this was followed by a quick reduction in the DAI until the mice were euthanized (Figure 1B); these results demonstrated that BRD7+/+ mice suffered more severe colitis after the 14th day, suggesting that the deficiency of BRD7 plays a protective role in the middle-late stage of CAC.