Furthermore, we performed H&E staining and found that BRD7–/– mice developed low-grade dysplasia, while BRD7+/+ mice displayed high-grade dysplasia characterized by loss of epithelial polarity (Figure 1E) and an increased tumor multiplicity in the colons, measured as the sum of tumor numbers and tumor volume, respectively (Figures 1F,G). This evidence concerns the gene BRD7 and neoplasm.