c-Myc, which serves as a crucial transcription factor, regulates over 15% of genes of the human transcriptome (Dang et al., 2006; Kress et al., 2015) and is ectopically expressed or hyperactivated in a wide variety of malignancies (Wolf et al., 2015; Xiao et al., 2017; Jung et al., 2018; Li et al., 2019), including CRC; and c-Myc knockdown significantly inhibited cell proliferation and tumor growth (Niu et al., 2015; Li et al., 2017; Wang et al., 2018), revealing that c-Myc could be a broadly applicable and promising therapeutic target. The gene discussed is MYC; the disease is neoplasm.