VEGFA and clear cell renal carcinoma: An interesting observation in clear cell renal cell carcinoma is that sunitinib can prevent VEGF-induced ESM-1 secretion by endothelial cells, but not regulate the TNF-α-induced ESM-1 secretion (56), suggesting that ESM-1 could be a potential biomarker to monitor the patient response to anti-VEGF therapies (56).