GTP-binding proteins Rho, Rac, Rab, Rap, Ras (Ras, Rho, Rab superfamily of GTPases) are all dependent from farnesylation and geranylgeranylation to exert their tumorigenic activities, which eventually promote cell cycle progression and cellular survival, as well as tumor cells motility, migration and metastasis (41, 161, 162). This evidence concerns the gene RHO and neoplasm.