PTEN and gastric cancer: Gastric cancer TDEs can activate angiogenesis by delivering several types of miRNAs to vascular endothelial cells, including miR-130a targeting c-MYB (108), miR-135b targeting FOXO1 (109), miR-155 targeting FOXO3 (110) and c-MYB (111), miR-23a targeting PTEN (112) (Figure 5).