Here, we aimed to evaluate the efficacy and safety of neoadjuvant EGFR-TKIs for lung cancer.<h4>Methods</h4>Published studies on neoadjuvant EGFR-TKIs in NSCLC were identified in PubMed, Web of Science, and EMBASE until June 1, 2020. The gene discussed is EGFR; the disease is non-small cell lung carcinoma.