As the major functional cytokine secreted by Breg cells, IL-10 production is related to the B-cell linker protein (BLNK) expression, which is involved in the regulation of the immune response in allergic and autoimmune diseases (88), it regulates the differentiation of Th1 cells and Th17 cells and inhibits T cell cytokine secretion resultantly (47). This evidence concerns the gene BLNK and autoimmune disease.