IGHE and allergic disease: Recently, Liu et al., working on a β-lactoglobulin-induced milk allergic mouse model, demonstrated that supplementation with 2’-FL for 4 weeks decreased IgE and β-lactoglobulin-specific IgE in the serum and increased the levels of the anti-inflammatory cytokines IL-10, TGF-β, and IFNγ compared to allergic mice untreated with 2’-FL, thus preventing allergy development (131).