Type I IFN positive plasmacytoid DCs (pDCs) and monocytes isolated from peripheral blood mononuclear cells of primary SS patients show upregulation of TLR7, as well as, the downstream signaling molecules MyD88 and IRF7, and the DC maturation marker, radical S-adenosyl methionine domain containing 2 (RSAD2) (40). The gene discussed is TLR7; the disease is synovial sarcoma.