TLR8 and systemic lupus erythematosus: In this context we have shown previously that TLR8-deficiency in C57BL/6 mice leads to lupus development due to increased TLR7 expression and signaling by DCs, and that this phenotype can be exacerbated under high fat diet conditions due to the additional increase of TLR7 signaling (10, 11, 26).