As described in the review by Caam et al., several studies have shown neutrophils, macrophages, NK cells, and Tregs to play a role in the profibrotic events in SSc by the production of profibrotic cytokines such as TGF beta, IL-4, IL-10, IL-13, etc., thus corroborating our findings (50). Here, IL10 is linked to systemic sclerosis.