While activation of CD4+ Th1 and impairment of CD4+ Tregs are essential for the pathology of rheumatoid arthritis (43), the DIME analysis of RA revealed several lymphoid cells such as CD4+ Tregs, CD4+ Th1, NK cells, etc., as the top DACs in the top cluster (Figure 3A). This evidence concerns the gene CD4 and rheumatoid arthritis.