Using DIME, the top DACs were found to be CD4+ Treg, CD4+ Th1, and NK cells in inflammatory arthritis (AS, PsA, and RA); neutrophils, granulocytes, and BDCA1+ CD14+ cells in SLE and SSc; ILC2, NK, CD4+ Th1, and CD4+ Treg in the IBDs. The gene discussed is CD4; the disease is systemic sclerosis.