KEGG pathway analysis of the subsets of genes linked to the Tem and Tcm-specific mDHSs identified in Figure 6D revealed a strong link to cytokines, cytokine and TCR signalling and Th cell differentiation in both subsets, whereas genes such as Nfkb1 and Mapk14 also had Tem-specific mDHSs linked to pathways associated with intracellular infections that drive Th1 responses (Human immunodeficiency virus 1 infection and Tuberculosis, Supplementary Table 2). This evidence concerns the gene NFKB1 and tuberculosis.