To this end we used C57BL/6 mice with transgenic expression of a functional natural resistance associated macrophage protein 1 (NRAMP1 or SlC11A1), which results in an improved host resistance to infections with S. Typhimurium and thus prolonged bacterial infection allowing to study T cell responses over time (Figure 2, Supplementary Figure 1). The gene discussed is SLC11A1; the disease is infection.