The infiltration of TAMs in tumors was mediated by numerous chemotactic factors produced by tumor cells and TME cells including C-C motif ligand 2 (CCL2), CX3C chemokine ligand 1 (CX3CL1), stromal cell-derived factor-1 (SDF-1), colony-stimulating factor-1 (CSF-1) and periostin (POSTN) etc. Here, CXCL12 is linked to neoplasm.