In summary, our study revealed that 1upregulation of PDCD10 is positively correlated with GAMs infiltration in GBM patients; 2upregulation of PDCD10 in GBM cells recruits and activates murine primary microglia, microglia- and macrophage-like cells in vitro and promotes tumor growth in vivo; 3PDCD10-overexpressed GBM cells increases the release of CXCL2, which activates CXCR2 and downstream Akt and Erk1/2 signaling in primary microglia, microglia- and macrophage-like cells. Here, MAPK3 is linked to glioblastoma.