Of note, IF-staining of Iba1 (green) revealed a significantly more microglia/macrophage infiltration in peri-tumor area and tumor edge (p<0.001, respectively) (Figure 4D) in oxPdcd10-group, suggesting a potential chemotaxis effect mediated by PDCD10 on microglia/macrophages which migrated from normal brain tissue towards homograft tumors. Here, AIF1 is linked to neoplasm.