Additionally, a significantly increased transcription of M2-markers, such as IL-10, IL-6 and arg-1 was detected in oxPDCD10-CM cultured primary microglia, microglia- and macrophage-like cells, suggesting that overexpression of PDCD10 in GBM triggered a pro-tumorigenic phenotype polarization. This evidence concerns the gene IL6 and glioblastoma.