Since we already know that exercise increases DBHB levels in the hippocampus where it increases Bdnf expression through HDAC inhibition (7) and that DBHB induces resistance to oxidative stress via HDAC inhibition (53), it is important to assess whether epigenetic mechanisms are involved in DBHB's neuroprotective effects considering the efficacy of HDAC inhibition as a therapy in mouse models of stroke (54, 55). The gene discussed is BDNF; the disease is Stroke.