Impairment of the NO-sGC-cGMP signaling pathway is associated with cardiovascular disease, diabetes, and pathogenesis of neurodegenerative diseases and has been observed in vascular dementia, AD, general cognitive impairment, and could lead to stroke (Bennett et al., 2009; Stephan et al., 2017; Casas et al., 2019a; Casas et al., 2019b). Here, SGCB is linked to Alzheimer disease.