Diaz-Perdigon et al. (2020) found that early SIRT2 inhibition by a selective SIRT2 inhibitor 33i might be beneficial for preventing age-related cognitive deficits, neuroinflammation, and AD progression in the senescence-accelerated mouse prone-8 (SAMP8) model, which provided new insights into AD therapy. The gene discussed is SIRT2; the disease is Alzheimer disease.