SIRT2 and Alzheimer disease: Though inhibition of SIRT2 improved memory in murine models (Biella et al., 2016), clinical evidence did not show correlations between the level of SIRT2 mRNA and cognitive performance of patients, and no difference in the level of SIRT2 mRNA in the periphery between normal senior people and AD patients was found (Wongchitrat et al., 2019).