Previous studies have corroborated that specific SIRT2 single-nucleotide polymorphisms (SNPs) correlate to the risk of a number of neurodegenerative diseases, like Alzheimer’s disease (AD) (Polito et al., 2013; Porcelli et al., 2013; Xia et al., 2014; Cacabelos et al., 2019; Shen et al., 2020) and Parkinson’s disease (PD) (Wang et al., 2018; Chen et al., 2019) under certain conditions. Here, SIRT2 is linked to Alzheimer disease.