Green et al. (2008) verified the effect of nicotinamide in the 3xTg AD mouse model: nicotinamide decreased the level of phosphorylated tau protein and increased its degradation. Nicotinamide is also protective in axonal degeneration by elevating the acetylation of microtubules (Wang et al., 2005) or reducing the deacetylation of tubulin (Suzuki and Koike, 2007). The gene discussed is MAPT; the disease is Alzheimer disease.