There was a significant association between TERT promoter mutation status and higher chondrosarcoma grade (p < 0.0001), as well as metastasis (p < 0.001), and both overall (p < 0.001) and disease-specific mortality (p < 0.001), but not with local recurrence (p = 0.390) (Table 1). The gene discussed is TERT; the disease is chondrosarcoma.