In this study, we identified that PRELID1P6, which was negatively regulated by miR-1825, bound to hnRNPH1 to prevent its Ub degradation in cell nucleus, which subsequently increased TRF2 expression by alternative splicing effect, activated the Akt/mTOR pathway, and promoted glioma cells proliferation and inhibited cell apoptosis. Here, AKT1 is linked to glioma.