DIRAS3 and hearing loss disorder: Overall, carriers of rare ARHI variants have a 2.2-fold (95% confidence interval (CI) = [1.8;2.7], P = 1.0 × 10−12) greater risk of mild hearing impairment than the rest of the population, 3.0-fold (CI = [2.1;4.3], P = 1.4 × 10−9) greater risk of moderate and 5.6-fold (CI = [3.1;10.2], P = 1.9 × 10−8) greater risk of severe impairment (DHS dataset, Fig. 2a).