BRCA1 and breast cancer: To evaluate the sensitivity of cancer cells and stromal fibroblasts to PARPis, five human BRCA1/2-wild type OC cell lines, SKOV3, OVCAR3, A2780, OVCAR8, and OV90; one strain of BRCA1/2-mutant OC cell line, SW626; and one strain of BRCA1/2-mutant breast cancer cell line, HCC1937; MRC5-CAFs; and four other primary CAFs were exposed to various doses of PARPis.