TP53 and acute leukemia: To this end, the panel of five acute leukemia lines with different p53 status (MOLM-13, MV4-11, Molt-4, HL-60, THP-1) were exposed to varying concentrations of M3814 at different AraC: DNR ratios (1:2, 1:1, 2:1, 4:1, 8:1) and their growth/viability was determined by the CTG assay (Fig. 6A).