As FLT3-ITD cells have been shown to be much more sensitive to sorafenib and sunitinib than FLT3 wild-type AML cells33, we first tested the effect of sunitinib on the growth/viability of the four AML cell lines, Molm-13, MV4-11, ML-2, M-07e (Fig. 3A). This evidence concerns the gene FLT3 and acute myeloid leukemia.