To assess its role in leukemia cell death, we measured the expression of several genes known to participate in the induction of extrinsic apoptotic signaling (TRAIL, TRAIL-R1, TRAIL-R2, JUN and CASP8)34, in Molm-13 cells exposed to DNR in the presence or absence of M3814 by qPCR (Fig. 4A). The gene discussed is CASP8; the disease is leukemia.