We examined the effect of the DNA-PK inhibitor on the p53 response to DSBs induced by IR in a small panel of acute leukemia cell lines, three of which express wild-type p53 (MOLM-13, Molt-4, MV4-11) and two are p53-deficient (THP-1 and HL-60). Here, PRKDC is linked to acute leukemia.