To determine the cut-off value of the gene ratios with prognostic utility, we partitioned the GC patients into 10 subsets according to the gene ratios and then performed survival analysis, which revealed that subset 10 with the highest gene ratios for EGFR, FGFR1, GATA6, IGF2, and SETDB1 was associated with worse clinical outcomes in patients with GC. Here, SETDB1 is linked to gastric cancer.