IL27RA and neoplasm: Specifically, compared with wild-type mice, WSX1−/− mice showed earlier tumor formation, more neoplastic lesions (P = 0.0012, Fig. 2g, h), increased liver weight (P = 0.0328, Fig. 2i), and significantly poorer survival (HR = 4.821, P = 0.0252, Fig. 2j).