SQSTM1 and dementia: In line with our previous findings23,25,27, dementia-like, but not autistic-like, behaviours (Supplementary Fig. 3a, aʺ) were concomitant with the age-dependent onset of autophagosome/lysosomal dysfunction as evidenced by increased LC3-II protein expression and an increase of one of its protein substrates, Sequestosome 1 (p62/SQSTM1) (Supplementary Fig. 3b, bʺ).