Five variants (High LDL: LDLR p.Glu101Lys, LDLR p.Asp266Glu, LDLR p.Gly592Glu, APOB p.Arg3527Gln; Low LDL: PCSK9 p.Tyr142Ter) were carried by individuals both in the phenotypically ascertained group and in the rest of the AMP-T2D-GENES cohort. This evidence concerns the gene PCSK9 and type 2 diabetes mellitus.