Laminin A1 secreted by CAFs, as well as tissue transglutaminase produced by PDAC cells, altered the response to gemcitabine,351 and breast CAFs increased MMP1 secretion synergistically with type IV collagen to promote Taxotere resistance via the TGF-β signaling, while GM6001 (an MMP1 inhibitor) recovered cancer cell chemosensitivity,352 perhaps by establishing physical barriers or inducing microvasculature compression through CAFs, and overcoming CAF-driven ECM hindrance of chemotherapeutic drugs delivery. The gene discussed is MMP1; the disease is cancer.