Importantly, in contrast to EGFR overexpression in tumor cells, which was positively correlated with the overall survival period of patients with several cancers,261 EGFR overexpression in CAFs had no significant relation to the prognosis of patients with colorectal cancer,246 indicating that EGFR in CAFs might not be an independent prognostic factor for survival evaluation in patients with cancers. The gene discussed is EGFR; the disease is colorectal cancer.