CD146, a cell membrane protein, was knocked down to promote CAFs activation, which might have been caused by the modulation of NF-κB activity.286 In another study, Wu et al. found that gastric cancer-derived HTRA1 promoted CAFs generation from NFs through the activation of the NF-κB/bFGF/FGF2 signaling pathway.287 Furthermore, CXCR2 signaling in CAFs promoted the CAF acquisition of secretory phenotype by activating NF-κB,288 noting that NF-κB signaling pathway was involved in regulating CAF factor secretion. This evidence concerns the gene NFKB1 and gastric cancer.