B7-H3 has been recognized as a co-stimulatory molecule in immune responses.129 In renal cell carcinoma, B7-H3 silencing increased apoptosis and prevented the cell cycle process and simultaneously inhibited AKT phosphorylation,130 suggesting that AKT pathways might play a role in promoting CAF proliferation and in inhibiting the apoptosis induced by B7-H3. This evidence concerns the gene CD276 and hereditary clear cell renal cell carcinoma.