Further, cytokine signaling of GP130-IL6ST/JAK1 cascade mediated actomyosin contractility in cancer cells and CAFs to promote SCC invasion.237 Estrogen in CAF-CM promoted gastric cancer cell proliferation and invasion via IL-6/STAT3 signal axis, and these two processes could be inhibited by an IL-6-neutralizing antibody and STAT3 siRNA, respectively.236. This evidence concerns the gene IL6ST and gastric cancer.