In prostate cancer, CAFs with high YAP1 expression could prompt the proliferation of cancerous epithelial cells and were more likely to cause the distant metastasis.47 Similarly, Shen et al. found that knocking down YAP1 or SRC in CAFs attenuated the promotion of CM on the proliferation and invasion capacity of human prostate cancer cells,47 indicating that CAFs in prostate cancer could promote tumor cell proliferation and invasion, which was highly dependent on the paracrine activity of YAP1 and/or SRC in CAFs. This evidence concerns the gene YAP1 and Familial prostate cancer.