SOAT1 and cancer: Constitutive activation of JAKs and STATs was first identified as being associated with malignancy,227 and accumulating evidence has shown that CAF-mediated JAK/STAT signaling pathway is widely involved in human cancers, including prostate,228 lung,229 breast,230 colorectal,231 gastric,232 endometrial,233 liver,234 and oral235 cancers, through various tumor biological processes, including in increased cell plasticity, proliferation, migration, invasion, EMT, angiogenesis, and metastasis.