LGI1 and viral encephalitis: Given that immunotherapy is more effective than antiseizure medications in treating LGI1-antibody-associated seizures, early treatment with immunotherapy has shown great promise for preventing otherwise incipient cognitive impairment and functional disability.40 In NMDAR-antibody encephalitis, early treatment independently predicted good outcome (modified Rankin score ≤2) whereas delays in immunotherapy of >4 weeks were associated with poor functional outcomes at 1 year.43 44