The expression of Kv7.1, Kv7.2, Kv7.3, Kv7.4 and Kv7.5 mRNA in the hypertension group was down-regulated significantly compared with the sham group (P < 0.05) while significantly up-regulated in allisartan treatment group compared with the hypertension group (P < 0.05) In MA, (Fig. 6). Here, KCNQ4 is linked to hypertensive disorder.