The mRNA expression of Kv7.1, Kv7.2, Kv7.3, Kv7.4 and Kv7.5 mRNA subunits was observed to be up-regulated in MAs while Kv7.1, Kv7.2 and 7.4 mRNA significantly down-regulated in aorta of animals treated with allisartan compared to hypertension induced untreated animals. The gene discussed is KCNQ1; the disease is Hypertension.