The expression of Kv7.1, Kv7.2 and Kv7.4 mRNA were significantly up-regulated in hypertension group compared with the sham group (P < 0.05) and were significantly down-regulated in allisartan treatment group compared with the hypertension group (P < 0.05) in aorta (Fig. 7). Here, KCNQ1 is linked to hypertensive disorder.