The etiology of PMS is unclear, multifactorial and complex and yet to be fully explained and may involve the influence of progesterone on certain neurotransmitters (e.g. serotonin, GABA, opioids, and catecholamine), elevated levels of prolactin or high sensitiveness toward the action of prolactin, insulin resistance, sensibility to endogenous hormones, altered hypothalamic-pituitary-adrenal axis role, nutritional deficiencies, changes in glucose metabolism, and alterations in fluid and electrolyte equilibrium [10]. Here, PRL is linked to premenstrual tension.