Then, we exported non-small cell lung cancer mRNA expression data from TCGA database, and performed co-expression analysis with CD151 and ITGA3 co-expression coefficient of 0.3, P < 0.05, and input the selected genes into FunRich software (version 3.1.3) for functional analysis, it can be seen that most of the genes are clustered in EGFR related pathways (Fig. 5b, c). This evidence concerns the gene ITGA3 and non-small cell lung carcinoma.