However, post-transcriptional regulator CALCOCO2 (NDP52), which plays an important role in degrading L1 RNA in the cytoplasm [35], was downregulated in the IPF patients and negatively correlated with the expression of L1HS (Fig. 2b and c, Supplemental Table 4C). This evidence concerns the gene CALCOCO2 and idiopathic pulmonary fibrosis.