The multivariate logistic regression model considered 8 parameters with P value < 0.05, including hypertension, serum albumin < 30 g/L, GOLD III–IV, oral or intravenous corticosteroids, use of broad-spectrum antibiotic longer than 10 days in last month, invasive ventilator utility, ICU admission 1 month previously and hospital acute exacerbation ≥ 2/year. This evidence concerns the gene ALB and hypertensive disorder.