Here, we showed that the size of renal glomerulus, body weight, the levels of blood glucose, serum lipids except HDL levels, urinary ACR, and serum creatinine were significantly increased in HFD-fed group as compared to the controls, whereas adiponectin treatment ameliorated HFD-induced obesity and ORG in mice (Fig. 7 a-e). The gene discussed is ADIPOQ; the disease is Obesity.