Accordingly, two recent studies using microglia depletion strategies via high doses of CSF1R inhibitors in the 5xFAD AD model showed that pre-plaque microglial depletion is sufficient to prevent the onset of plaque pathology (Sosna et al., 2018; Spangenberg et al., 2019) via unknown mechanisms. The gene discussed is CSF1R; the disease is Alzheimer disease.