Compared to SCR Calu1 tumours, m126+i221 Calu1 tumours also displayed an increase in the number of cleaved caspase 3‐positive cells and a downmodulation of phosphor‐AKT (Fig. 5B and Fig. S8B), overall suggesting that mir126+i221 treatment was able to induce apoptosis and antitumour effect also in this NSCLC cell line. This evidence concerns the gene AKT1 and neoplasm.