SPP1 and lymphoma: In our murine model of CNS neuroinvasion of EBV+ lymphoma cells, RNA-Seq analysis of MUN14 cells isolated from the brain revealed that this neuroadapted line overexpresses a number of host factors that are known to be upregulated in PCNSL, including the stromal cell derived factor-1 (SD-1)-CXCR4 signaling pathway, TSPAN13, germinal center signaling and motility protein (GCSAM), and OPN/SSP1, [66–69] (Fig 4A).