It has long been appreciated that increased OPN expression is associated with increased autoantibody secretion and, in the case of Sjögren’s disease, increased lymphocytic infiltration into salivary tissue—the target of the autoimmune response in that disorder [75,76] [76].Therefore, osteopontin may be involved in the CNS invasion of other pathogenic and autoreactive B-cells into the CNS and contribute to the neuropathogenesis of CNS inflammatory disorders, including MS. The gene discussed is SPP1; the disease is myeloid sarcoma.