GBA1 and Parkinson disease: Finally, we investigated neuroinflammation in the midbrain and striatum of GBA1 D409V KI mice due to associations with GBA and neuroinflammation in GD and PD patients and reports of increased microgliosis and astrogliosis in the hippocampus of the GBA1 D409V KI model at 12 months of age (Table 1) [30].