Indeed, using a chemical chaperone, 4-PBA, that inhibits the PERK and the ATF6 pathways and potentiates the IRE1α pathway, we achieved a significant 3.74-log (5,623-fold) reduction in virus titer, suggesting that potent inhibition of ZIKV infection may require synergistic manipulation of the three UPR arms. Here, ATF6 is linked to Zika virus infectious disease.