CRH and insomnia: ACTH reaches the adrenal glands through peripheral blood circulation, and causes the release of corticosterone, cortisol, and other substances by ACTH.[14] It has been previously reported that CRH/CRHR1 pathway in the hypothalamus can regulate sleep related mechanism(s), but evidence to support the results are not consistent, and findings are more focused on the downstream pathways associated with metabolism such as detection of ACTH, cortisol, etc. However, there is no exact experimental data to indicate that how patients with insomnia could exhibit stress response in the hypothalamus.