CRHR1 and insomnia: Therefore, the proposed hypothesis that the treatment of insomnia by abdominal vibration and ring massage could be related to the intervention of hypothalamic CRH/CRHR1 signaling pathway, activation of HPA axis, regulation of different mediators such as ACTH, COR, 5-HT, GABA, and other metabolites in the body, thus contributing to the maintenance of neuroendocrine homeostatic state will be analyzed.