It is mainly due to the increase of effective renal filtration pressure caused by hypertension and glomerular hyperperfusion and hyperfiltration caused by the increase of glomerular plasma flow.[31,32] GDI can prevent angiotensinogen from converting into angiotensin I and II by inhibiting angiotensin-converting enzyme, thus reducing the damage of renal interstitium caused by high pressure and hyperperfusion. The gene discussed is ACE; the disease is Hypertension.