INS and diabetes mellitus: In the same time, the newly produced insulin after the first 10 minutes is considered to be the second phase (SPIS).[4] Finally, glucose has the ability to eliminate itself independent of the insulin action which is termed as glucose effectiveness (GE).[5] It is interesting that some researchers think that it is even more important than the aforementioned 3 factors, in the present study, they were denoted as diabetes factor (DF).