Although inhibiting a single target gene, such as ROCK1 and NGFR, can sensitize vemurafenib-resistant melanoma cells14,24, our results showed that pair-wise perturbation of ROCK1 + NF2 or NGFR + NF2 conferred a strong protective phenotype during vemurafenib treatment (Supplementary Figure S5A and S5B). The gene discussed is NF2; the disease is melanoma.