CRP and Insulin resistance: Interestingly, other authors observed that in non-obese euthyroid individuals TPOAb titers were associated with HOMA1-IR and C-reactive protein levels, independent of thyroid function and these observations suggested that mild deviation of thyroid function within the normal range, chronic inflammation, and insulin resistance may be a link between thyroid autoimmunity and metabolic abnormalities in the non-obese population [29].