Finally, considering that the occurrence of glioblastoma multiform, the most malignant glioma, is highly relevant with changes in the factors of the epidermal growth factor receptor (EGFR) and PI3K/Akt/mechanistic target of rapamycin kinase (mTOR) signaling pathways (Chakravarti et al. 2004; Li et al. 2016), we investigated the alterations in the PI3K/AKT signaling in response to RNF139 overexpression or knockdown. Here, EGFR is linked to central nervous system cancer.