Interestingly, RNF139 has been previously regarded as a tumor-suppressive factor in several cancers, including tongue cancer (Wang et al. 2017), renal cancer (Brauweiler et al. 2007), kidney carcinoma A498 cells, osteosarcoma U2OS cells, and cervical carcinoma HeLa cells (Lin et al. 2013). This evidence concerns the gene RNF139 and osteosarcoma.