PIK3CA and cancer: The aggressiveness of cancer cells could result from the deregulation of complex alternate signaling pathways (Alifieris and Trafalis 2015); among the deregulated signaling pathways, the PI3K/AKT signaling showed to be a crucial one in glioma pathogenesis (Tong et al. 2016; Wen and Kesari 2008; Zhao et al. 2017).