In concert with these imaging biomarkers of both mechanical properties, ECM architecture, and T cell migration, we explored the consequences of altering the ECM by inhibition of the lysyl oxidase (LOX), a copper-dependent enzyme responsible for the crosslinking of collagen molecules into fibers that has been seen to be overexpressed in many metastatic tumors and responsible for malignant progression (Cox et al., 2016). This evidence concerns the gene LOX and metastatic neoplasm.