The carriers of ApoE4 show greater breakdown of BBB by age compared to ApoE2 or ApoE3 alleles, which leads to considerable albumin levels in the CSF.[135] Furthermore, brain samples from AD cases homozygous for ApoE ε4 showed increased deposition of fibrin(ogen) specifically in CAA and oligomeric Aβ‐positive vessels compared with AD ApoE ε2 and ε3 allele carriers.[136]. The gene discussed is APOE; the disease is Alzheimer disease.