AKT1 and cancer: Jak‐STAT pathway is a principal signaling for many cytokines and growth factors and thus closely related to certain diseases, including cancer.[23] The administration of STAT3 inhibitor (Cryptotanshinone) showed stronger inhibition (46.60%) on the proliferation of HCC272 than other inhibitors targeting AKT or MEK (Figure 3H), suggesting the large dependence on Jak‐STAT3 signaling in CD44+ cells to form the drug resistance of organoid HCC272.