GAPDH is a well‐known housekeeping gene, whereas recent studies reported that it could promote liver tumorigenesis by modulating glycolysis.[24]NEAT1 is a nuclear lncRNA that is an essential structural component of paraspeckles, which leads to HCC progression in response to hypoxia stress.[25] UMAP analyses showed that these genes were up‐regulated with different degree in individual organoid sample (Figure 4C). This evidence concerns the gene GAPDH and hepatocellular carcinoma.