Since GAPDH‐enriched cluster with high metabolic status plays a pivotal role in shaping the hypoxia tumor environment, we examined the gene expression pattern of GAPDH‐enriched clusters and identified the common shared genes including GAPDH, NDRG1 (N‐Myc downstream regulated 1), ALDOA, and CA9 in these metabolism advantage organoids. This evidence concerns the gene ALDOA and neoplasm.