The epidermal growth factor receptor (EGFR) pathway plays an important role in the carcinogenesis of HCC and could mediate the expression of NEAT1. [28, 29] Meanwhile, the interaction of CD74‐MIF could mediate pathologic proliferation of T3 cluster.[30] Interestingly, CellPhoneDB analyses revealed the similar feedback regulation from T3‐NEAT1high to T1‐GAPDHhigh. This evidence concerns the gene EGFR and hepatocellular carcinoma.